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PrrF RNA
The PrrF RNAs are small non-coding RNAs involved in iron homeostasis and are encoded by all ''Pseudomonas'' species. The PrrF RNAs are analogs of the RyhB RNA, which is encoded by enteric bacteria. Expression of the PrrF RNAs is repressed by the ferric uptake regulator (Fur) when cells are grown in iron-replete conditions. Under iron limitation, the PrrF RNAs are expressed and act to negatively regulate several genes encoding iron-containing proteins, including SodB and succinate dehydrogenase. As such, PrrF regulation "spares" iron when this nutrient becomes scarce.
== PrrF and virulence ==
In ''Pseudomonas aeruginosa'', the PrrF RNAs are required for the production of the Pseudomonas quinolone signal (PQS), a quorum sensing molecule that activates the expression of several virulence genes. The phenomenon is mediated by PrrF repressing the expression of enzymes that degrade anthranilic acid, which is the precursor for PQS synthesis.〔Oglesby, A.G., Farrow, J.M., 3rd, Lee, J.H., Tomaras, A.P., Greenberg, E.P., Pesci, E.C., and Vasil, M.L. (2008). (The influence of iron on Pseudomonas aeruginosa physiology: a regulatory link between iron and quorum sensing. ) J Biol Chem 283, 15558-15567. doi: 10.1074/jbc.M707840200.〕 Due to this regulatory link with PQS, the PrrF RNAs are predicted to play a role in pathogenesis.
The PrrF RNAs of ''P. aeruginosa'' are unique from other ''Pseudomonas'' species, in that they are encoded by two highly homologous genes, ''prrF1'' and ''prrF2'', which are located in tandem on the chromosome. The tandem arrangement of the ''prrF'' genes allows for the expression of a third, heme-regulated non-coding RNA named PrrH, which regulates genes involved in heme homeostasis.〔Oglesby-Sherrouse, A.G., and Vasil, M.L. (2010). (Characterization of a heme-regulated non-coding RNA encoded by the prrF locus of Pseudomonas aeruginosa. ) PLoS ONE 5, e9930.〕 Heme is an abundant source of iron in the human host, and ''P. aeruginosa'' is the only ''Pseudomonas'' species capable of causing infection in humans. Therefore, it is hypothesized that the PrrH RNA plays a role in ''P. aeruginosa's'' adaptability as a human pathogen.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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